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High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques. The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates. Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff. Shows the reader exactly how to perform modern bioanalytical sample preparation techniques, complete with detailed strategies Thorough literature review and summary of published information Detailed discussion and examples of the method development process.

Drugs --- Pharmaceutical industry --- Metabolic Phenomena --- Pharmacological Phenomena --- Kinetics --- Natural Science Disciplines --- Investigative Techniques --- Fluids and Secretions --- Chemicals and Drugs --- Evaluation Studies as Topic --- Drug Discovery --- Body Fluids --- Chemistry --- Methods --- Drug Evaluation, Preclinical --- Chemistry Techniques, Analytical --- Metabolism --- Pharmacokinetics --- Pharmaceutical Preparations --- Biochemical Phenomena --- Phenomena and Processes --- Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Anatomy --- Disciplines and Occupations --- Chemical Phenomena --- Analysis --- Technological innovations

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Human medicine --- Business policy --- Acupuncture --- Small business --- Health Services Administration --- Morals --- Health Occupations --- Professional Practice --- Risk Management --- Investigative Techniques --- Safety --- Disciplines and Occupations --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Health Care --- Accident Prevention --- Psychology, Social --- Accidents --- Behavior and Behavior Mechanisms --- Public Health --- Psychiatry and Psychology --- Environment and Public Health --- Safety Management --- Private Practice --- Ethics --- Practice Management --- Methods --- Organization and Administration --- Practice --- Management

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"A comprehensive, neurally based theory of language function that draws on principles of neuroanatomy, cognitive psychology, cognitive neuropsychology, psycholinguistics, and parallel distributed processing."--Provided by publisher.

LANGUAGE ARTS & DISCIPLINES --- Linguistics / General --- Neurolinguistics --- Language and languages --- Mental Processes --- Psycholinguistics --- Learning --- Models, Psychological --- Central Nervous System --- Models, Neurological --- Psychological Phenomena and Processes --- Behavioral Sciences --- Models, Biological --- Models, Theoretical --- Psychology, Educational --- Nervous System --- Linguistics --- Language --- Anatomy --- Behavioral Disciplines and Activities --- Psychiatry and Psychology --- Investigative Techniques --- Psychology, Applied --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Communication --- Information Science --- Neurolinguistic Programming --- Brain --- Cognition --- Human Anatomy & Physiology --- Health & Biological Sciences --- Neuroscience --- Grammars --- Neurolinguistics. --- Grammars. --- Grammar --- Grammar, Polyglot --- Polyglot grammar --- Neuro-linguistics --- Biolinguistics --- Higher nervous activity --- Neuropsychology --- LINGUISTICS & LANGUAGE/General --- NEUROSCIENCE/General

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This title offers a novel explanation of delusion. Over the last two decades, philosophers and cognitive scientists have investigated explanations of delusion that interweave philosophical questions about the nature of belief and rationality with findings from cognitive science and neurobiology. The book argues that once we fully describe the computational and neural mechanisms that produce delusion and the way in which conscious experience and thought depend on them, the concept of delusional belief retains only a heuristic role in the explanation of delusion.

Neuropsychiatry. --- Mental Processes --- Behavioral Sciences --- Delirium, Dementia, Amnestic, Cognitive Disorders --- Behavioral Symptoms --- Models, Theoretical --- Investigative Techniques --- Behavior --- Psychological Phenomena and Processes --- Mental Disorders --- Behavioral Disciplines and Activities --- Psychiatry and Psychology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Behavior and Behavior Mechanisms --- Delusions --- Cognition Disorders --- Psychology --- Theory of Mind --- Models, Psychological --- Medicine --- Health & Biological Sciences --- Neurology --- Behavioral neurology --- Theory of Mind. --- Models, Psychological. --- psychology. --- Model, Mental --- Model, Psychological --- Models, Mental --- Models, Psychologic --- Psychological Models --- Mental Model --- Mental Models --- Model, Psychologic --- Psychologic Model --- Psychologic Models --- Psychological Model --- Mentalizing --- Mentalizings --- Biological psychiatry --- PHILOSOPHY/Philosophy of Mind/General --- COGNITIVE SCIENCES/Psychology/Cognitive Psychology --- NEUROSCIENCE/General --- Philosophical anthropology --- Cognitive psychology

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In this engaging, even lyrical, book, Jan Lauwereyns examines the neural underpinnings of decision-making, using 'bias' as his core concept rather than the more common but noncommittal terms 'selection' and 'attention'.

Mathematical statistics --- Physiology of nerves and sense organs --- Neural circuitry --- Decision making --- Bayesian statistical decision theory. --- Neural networks (Neurobiology) --- Nerve Net --- Judgment --- Models, Theoretical. --- Mathematical models. --- Physiological aspects. --- physiology. --- Bayesian statistical decision theory --- Physiology --- Models, Theoretical --- Thinking --- Nervous System --- Investigative Techniques --- Biological Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Mental Processes --- Anatomy --- Disciplines and Occupations --- Psychological Phenomena and Processes --- Psychiatry and Psychology --- Neuroscience --- Human Anatomy & Physiology --- Health & Biological Sciences --- Mathematical models --- Physiological aspects --- Biological neural networks --- Nets, Neural (Neurobiology) --- Networks, Neural (Neurobiology) --- Neural nets (Neurobiology) --- Bayes' solution --- Bayesian analysis --- Deciding --- Decision (Psychology) --- Decision analysis --- Decision processes --- Making decisions --- Management --- Management decisions --- Circuitry, Neural --- Circuits, Neural --- Nerve net --- Nerve network --- Neural circuits --- Neurocircuitry --- Neuronal circuitry --- Cognitive neuroscience --- Neurobiology --- Statistical decision --- Choice (Psychology) --- Problem solving --- Electrophysiology --- Nervous system --- Reflexes --- NEUROSCIENCE/General --- COGNITIVE SCIENCES/General --- Physiology.